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mansoni X-ray structures of TGR 2X99, 2X8G, 2X8H 75 , 6FP4, 6FTC 33 , 6ZST, 6ZP3, 6ZLP, 6FMU, 6ZLB, 7B02, 7NPX 34 , 2V6O 75 ,6RTJ, 6RTO, 6RTM 36 , 3H4K 76 were downloaded from PDB, aligned in MOE, water molecules in the doorstop pocket were extracted and saved for visualization in Pymol

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